Liverpool manager, Jurgen Klopp, is expected to use ‘fresh legs’ against Midtjylland.
The Reds have already finished on top of Group D heading to Denmark.
Asked if several youngsters could play on Wednesday, Klopp replied: “We will see. It’s not unlikely but not decided yet.
“The job is to get in fresh legs, very important to get quality to change as much as you have to. It’s pretty much led not by me, it’s by the schedule.
“This game is Wednesday, which is of course absolutely fine, three days after the last game. The next game is on Sunday [against] Fulham, on Wednesday Tottenham, Saturday 12.30 [at] Crystal Palace. That means in 10 days or so, four games. That’s massive and we have to consider that.